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As would be expected given these deficiencies in translation efficiency and fidelity, pre-leukemic Rps15 -mutated B cells exhibit decreased ribosome maturation and cellular proliferation (consistent with previous findings in HEK293T cells 34 ), as well as increased ROS and activation of DNA damage response, while also exhibiting proliferative cell signals (increased ZAP70 and Myc activation) (Fig
Oncogenic Potential (Cancer Risk) Both peptides encourage angiogenesis (blood vessel growth) and cell proliferation
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The endogenous synthesis amounts to about 15 mg a day with uninterrupted energy metabolism
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