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This is arguably the most insidious risk of expired semaglutide
Clinical trial data shows retatrutide has somewhat higher rates of GI side effects (nausea, diarrhea, vomiting) compared to tirzepatide, likely due to the additional glucagon receptor activation
But for some people, maintaining healthy levels of uric acid can be more difficult
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Conservative strategies include progressive resistance training to rebuild core stability, regular stretching and mobility work, adequate hydration (often challenging on GLP-1 therapy), and micronutrient supplementation including vitamin D3, calcium, and B12
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