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18 Here, we provide an integrated overview that categorizes resistance based on cellular origin, molecular alterations, and therapy type (Fig
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Nrf2/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS
Kosower et al [11] had previously reported that monobromobimane (a derivative of 1,5-diazobicyclo[3,3,0] actadiendiones) and non fluorescent compound with an electrophilic site, slowly reacted with glutathione to form fluorescent glutathione conjugate and that the reaction might be catalysed by glutathione transferase
