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Nonetheless, in patients at high risk of sarcopenia, tailored management including nutritional optimization and concurrent resistance training should be considered to mitigate potential adverse consequences during pharmacologically induced weight loss [20]

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The most common side effects of semaglutide are gastrointestinal, including abdominal discomfort and nausea

However, phosphorylated GSK-3 was significantly upregulated on day 21 in the Liraglutide group, suggesting enhanced Wnt-signaling repressing adipogenesis [20]