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15 Under normal physiological conditions, a decrease in Na+ delivery to the macula densa due to either hypotension or hypovolemia reduces adenosine production
Diabetes Care 45 , 27492752 (2022)
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Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)
5 Epigenetic reprogramming and metabolic adaptation further enable phenotypic plasticity, while genetic alterations such as secondary mutations and gene amplifications sustain oncogenic signaling and confer drug tolerance
