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The pivotal GLP-1 trials the ones generating the headline weight loss numbers were run mostly in younger, premenopausal participants

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GLP-1 receptors are also present in the central nervous system, particularly in appetite-regulating centers of the hypothalamus, where activation promotes satiety and reduces food intake

Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly GLP1 2.4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial

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