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GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]
Planet Source Glutathione Capsules do just that
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15:30071 Topically applied GHK as an anti-wrinkle peptide: advantages, problems and prospective Pickart L, Vasquez-Soltero JM, Margolina A., BioMed Research International , 2015
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