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NLRP3 inflammasome in cardiovascular diseases: pathophysiological and pharmacological implications

These figures came from different trials, with different durations, dose schedules, and patient populations they were never compared head-to-head, so the percentages are not directly subtractable

However, they work through different mechanisms to activate AMPK

A landmark 2023 SELECT trial found that semaglutide reduced major cardiovascular events (heart attack, stroke) by 20% in patients who were overweight or obese regardless of whether they had diabetes

Addressing the cost barrier According to a November 2025 poll from the Kaiser Family Foundation, 1 in 8 adults in the U.S