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Percentages of proliferative (BrdU + ) (n = 6 technical replicates representative of 2 independent experiments) ( a ) and apoptotic (Annexin V + ) (n = 3 technical replicates representative of 3 independent experiments, **p = 0.0042) ( b ) cells were determined

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255,455 Hepatocyte-specific loss of RNF43/ZNRF3 disrupts lipid metabolism, leading to increased unsaturated fatty acid biosynthesis and altered lipid zonation