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This is generally a passive process driven by transpiration pull (Kumar and Biswas, 2023)

Apigenin treatment lowered the protein expression levels of HDAC1, 3, 4, 5, 6, and 8 in the mouse skin cancer cell line in a dose-dependent manner (Paredes-Gonzalez et al., 2014)

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Safety and Monitoring Considerations Regular monitoring of GH levels, IGF-1 concentrations, and thyroid function is recommended every four weeks