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As with any blend, the position to state plainly is that the combination itself has not been studied: no published work has examined these four compounds co-administered, and no synergy among them has been demonstrated
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Although glitazone therapy can reduce cardiovascular events in selected populations [129], these agents also increase the risk of clinically apparent heart failure and of fractures [129, 130], which in turn may reduce physical function and worsen sarcopenia
These findings were insufficient to interpret as positive immunoreactivity
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