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Even though the 3D structure of OCTN2 is still not known, the molecular determinants for substrate specificity have been revealed: one ammonium and one carboxylate groups are strictly required for transport, while the distance between them is not important (Ohashi et al., 2002
The interaction hypothesis rests on the individual mechanistic profiles of the components: BPC-157 and TB-500 address pro-angiogenic and actin-based tissue reconstruction
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