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Reactions that spread beyond the immediate injection area, involve significant swelling, or are accompanied by fever or systemic symptoms require medical evaluation

However, both can cause gastrointestinal side effects that may be additive, and dehydration from these effects could affect methotrexate clearance

Clinical data show a dose-response pattern: the 12 mg dose led to the biggest liver fat drop, at up to 86%

During these early weeks, peak concentrations are lower because you're still on starter doses

Some physicians advocate spending eight weeks at each dose rather than four, giving the body more time to respond before increasing