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International Journal of Endocrinology , 2024, Article ID 1023847
On the basis of the ability of GLP-1RA/tesaglitazar to induce neuronal activation in the hypothalamus, and recent data indicating that PPAR might affect systemic energy metabolism via hypothalamic neurocircuitries 5,6 , we next assessed the response of the hypothalamic proteome of DIO mice 10 h after single peripheral (s.c.) drug treatment using liquid chromatographymass spectrometry (LCMS)
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In the eWAT, no group separation was observed in the PCA, and only five and three proteins were upregulated by GLP-1GIPLani and GLP-1GIP, respectively (Extended Data Fig
PubMed Central, Malaspina, Patrizia, et al
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