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Unlike many therapeutic peptides that require cyclization or chemical modification to resist enzymatic breakdown, DSIP is a naturally occurring endogenous compound found in mammalian brain tissue, cerebrospinal fluid, blood plasma, and even peripheral organs

It is a short-lived signaling molecule involved in vascular tone, endothelial function, neurotransmission, inflammatory signaling, and tissue stress responses

The primary mechanism of NO mediated wound healing is the formation of new blood vessels in a process called angiogenic repair

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