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When Madeson shared his data with Knudsen in 1995, she realised that it rang a bell because she had noticed that both normal and obese rates experienced a lasting and reversible weight loss when given one of her early GLP-1 analogues

doi: 10.1128/mBio.02481-14 8 AriasNArboleyaSAllisonJKaliszewskaAHigarzaSGGueimondeMet al

The trajectory is steep through month six and then begins to gradual flatten, not because the medication stops working, but because the caloric deficit narrows as body weight decreases

Originally developed to regulate blood sugar in people with diabetes, GLP-1 treatments have been clinically proven to also support significant, sustained weight loss

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