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This 12-month analysis reveals a $1,600 difference between the least expensive option (Henry Meds at $2,388) and the most expensive (Noom Med at $3,988)

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The FTO gene variant (rs9939609) and MC4R gene variant (rs17782313) also shape your weight loss biology and may indicate whether you'll respond optimally to semaglutide alone or benefit from combination peptide therapy

Some people progress quickly through dose increases with minimal side effects, while others need more time at each level

Theres also a practical challenge: Health insurers dont typically cover obesity medications, says Scott Kahan, an obesity doctor and professor at Johns Hopkins Bloomberg School of Public Health and the George Washington University School of Medicine