Some patients may notice mild side effects, such as an upset stomach, which can often be managed with dietary adjustments and guidance from healthcare professionals
Other priority research questions to be addressed relevant to repurposing GLP-1 RAs as psychiatric drugs include target engagement studies, CNS penetration, drug-drug interaction studies with concomitant drugs, dose-finding studies, and health systems research that endeavors to determine optimal integrated care pathways
The medication was approved by the FDA in November 2015, and the current cost of Darzalex (20 mg/mL) is approximately $714 for a 5 mL supply
If microdosing maintains appetite suppression comparable to weekly dosing, that is a positive indicator
Gradual Dose Escalation Gradual dose escalation proceeds with: Weeks 1-4: 1 mg once daily Weeks 5-8: 2 mg once daily Thereafter: Adjustment based on individual response and goals Dosing Frequency Options Dosing frequency most commonly involves once daily administration (morning or evening), with alternative protocols using 2-3 times per week at 2 mg per injection