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Dr Aronne concludes: Our study shows that treatment with tirzepatide was superior to semaglutide with respect to reduction in body weight and waist circumference. Reference: Tirzepatide as Compared with Semaglutide for the Treatment of Obesity by Louis J
Vidya Ganesh , Daniel W
There are six binding proteins, each with a different affinity for IGF-1
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In the head-to-head SURMOUNT-5 trial (NEJM 2025), tirzepatide produced 20.2% weight loss vs 13.7% for semaglutide at 72 weeks
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