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Extensive research has established glutathione peroxidase 4 (GPX4) as a critical regulator in the pathogenesis of multiple pathological conditions, including osteoarthritis 35 ,cancers 47 , and liver disease 48
Published 2004
3D: three-dimensional 8-NG: 8-nitroguanine 8-OHdG: 8-hydroxy-2-deoxyguanosine BMI: body mass index BSA: body surface area D: day DUOX1: dual oxidase 1 eNOS: endothelial nitric oxide synthase GFR: glomerular filtration rate H 2 O 2 : hydrogen peroxide HCT: hematocrit test iNOS: inducible nitric oxide synthase IR: ionizing radiation ML: machine learning NADPH: nicotinamide adenine dinucleotide phosphate CTCAE: Common Terminology Criteria for Adverse Events O 2 : superoxide anion radical ONOO : peroxynitrite anion RID: radiation-induced dermatitis RISRs: radiation-induced skin reactions RNS: reactive nitrogen species ROS: reactive oxygen species NO: nitric oxide OH: hydroxyl radical This work incorporates data from the doctoral thesis of Dr
The mechanism involves upregulation of VEGF expression a key growth factor in new blood vessel formation and activation of ERK1/2 signaling pathways that drive cell proliferation, migration, and angiogenesis
33 , 19741987 e1979 (2021)
