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When theres sub-optimal glucose and highly active neurons have limited access to energy, they dysfunction and ultimately die on a chronic basis. The most active neurons are in regions of learning and memory, Fillit said, making them more susceptible to glucose deprivation and, ultimately, neurodegeneration

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The GSH-GSSG pair acts as the redox buffer within the glutathione system, preserving optimal redox balance in subcellular structures to the entire organism [4]

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Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors