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This leads to several effects, like slowing down gastric emptying, i.e
Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells
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Additionally, mutational studies suggest that L 388 is an important residue for GLP-1 signaling
