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This is because the risk of toxicity and serious adverse effects from an overdose is rare

This method puts the vitamin directly into a muscle

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Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses

By reducing nicotinamide methylation, supports cellular NAD+ availabilitya critical coenzyme for mitochondrial function, energy metabolism, and cellular repair