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All Letco APIs are of the highest pharmaceutical grade and comply, where applicable, with the current requirements of pharmacopoeial standards (USP-NF, BP, EP or equivalent)

Is the acetate salt of a synthetic cyclic heptapeptide with the sequence cyclo-(Ac-Nle4-cyclo[Asp5-His6-D-Phe7-Arg8-Trp9-Lys10])-NH2, representing a conformationally constrained, metabolically stabilised derivative of the -MSH(4-10) pharmacophore core in which the Asp5 and Lys10 side chains are bridged by a lactam bond to form the cyclic backbone, Nle4 replaces methionine to prevent oxidative inactivation, and D-Phe7 replaces native phenylalanine to confer endopeptidase resistance and stabilise the receptor-binding pharmacophore conformation

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One milliliter of culture was then back-diluted again into each of two flasks containing (1) 49 ml of DRM supplemented with 50 g ml 1 carbenicillin, 50 g ml 1 spectinomycin, 20 M arabinose and 20 g ml 1 chloramphenicol or (2) 49 ml of DRM supplemented with 50 g ml 1 carbenicillin, 50 g ml 1 spectinomycin and 20 M arabinose

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