glp 1 effects on inflammation Beyond metabolic benefits: The underexplored immunomodulatory of -1/glucagon agonists GLP-1 Agonists in Cardiovascular Diseases:

Richard Horowitz describes the Jarisch-Herxheimer (JH) flare as a temporary worsening of the symptoms of Lyme disease that occurs when the Lyme spirochete is being killed off by antibiotics, creating inflammationThese JH reactions produce cytokines (TNF-alpha, IL-6, and IL-8), which then create inflammatory symptoms, including increased fever, muscle and joint pain, headaches, cognitive impairment, and a general worsening of the underlying symptomology

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Reports of phase 2 data using 9 mg shows a placebo-adjusted mean weight loss of 15.4% after 24 weeks and 18.6% after 48 weeks (89)

Cell Death Dis 14 , 131 (2023)