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While there were no differences in creatinine concentration and uric acid

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Ex-4 relieved the leakage of the BBB while reduced levels of astrocyte-derived MCP-1, CXCL-1 MMP-9, and VEGF-A in ischemic areas after MCAO in rats ( Powerful internal mechanisms of protective efficacy among organs are activated via remote ischemic conditioning (RIC) which could be activated by cycles of ischaemia/reperfusion (I/R) exerted to a tissue or an organ which is far from the tissue/organ being sheltered (143)