4-HNE represents a highly reactive lipid peroxidation byproduct that induces cellular damage by interacting with proteins, DNA, and other cellular components through iron- and oxygen-mediated chain-breaking reactions ( The transient receptor potential channel TRPM4 has been shown to promote ox-LDL-induced dysfunction in HCAECs through ferroptosis mechanisms (33)
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Dr Dinesh Mahendran, Consultant Endocrinologist at The Metabolic Clinic, was invited to share insights on CNA938 on the complex relationship between obesity, hormones, stress and mental health, and explains why weight gain is often driven by metabolic and hormonal factors rather than willpower alone