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As this was the first research of its kind to report a link between NAION and semaglutide use, the study authors concluded that it did not establish a causal relationship between the two. Thus, they recommended future investigation into this association should involve one of the following: Larger, retrospective, multicenter, population-based study Prospective, randomized clinical trial (RCT) Post-market analysis of all GLP-1 RA drugs

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276 Additionally, tri-agonist treatment resulted in apoptosis, synaptic loss, inflammation, amyloid levels and oxidative stress being reduced

A spokesperson for Eli Lily did not immediately respond to a request for comment on when its own drug's sales would begin in China or how many doses would be supplied

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