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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]
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The mRNA levels of the antioxidant gene sod2 were decreased in all three recombinant cell lines compared to the control cell line before IBDV infection, with the most pronounced decrease in the mRNA levels of the sod2 gene in the recombinant GSS-M cell line (Fig
These effects mirror those observed with other incretin-based therapies but may be amplified by the peptides triple-agonist design
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