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Collectively, these innovations hold the potential to reduce required sample sizes, shorten trial durations, and improve statistical power, thus addressing some of the most persistent limitations in the development and validation of neuroprotective therapies [610]
Pickart would spend the next 46 years expanding on that discovery (he died in 2023)
167,171,172 Management strategies focus on tight glycemic control to prevent further nerve damage, symptomatic treatment with analgesics for pain management, physical therapy to maintain muscle strength and prevent contractures, and surgical interventions for entrapment neuropathies when necessary
Handling should be performed only by trained personnel using appropriate PPE, labeling, and documentation controls
Based on these data, the best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to environmental effects
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