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423 The atherogenic, proinflammatory and prothrombotic properties of Lp(a) contribute to its role in ASCVD pathogenesis 424 Notably, 7090% of the serum Lp(a) concentration is genetically determined by the expression of the LPA gene 425,426 and is largely unaffected by diet and lifestyle modifications

Carnitine deficiency is defined biochemically as abnormally low plasma concentrations of free carnitine, less than 20 mol/L at one week post term and may be associated with low tissue and/or urine concentrations

Monitoring disease progression and treatment response with acylcarnitines Dynamic alterations in the carnitine profile are closely linked to staging and progressionof DKD [47]