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All procedures related to the handling, care and treatment of animals were conducted in accordance with University of Michigans Committee on the Use and Care of Animals guidelines
Phase 2 dose-finding trial (Lancet 2021) showed clear dose-response from 0.3 mg up to 4.5 mg/week, but 2.4 mg is the dose Novo Nordisk advanced into Phase 3 and is the most commonly self-reported community ceiling
Pink (lighter B12 dose) and red (standard B12 dose) are both within normal range
Insurance coverage and prior authorization can change out of pocket costs
2.4 mg was the dose advanced into Phase 3 because the efficacy/tolerability ratio peaked there
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