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GLP-1 medications are a smaller but not free lunch, as they can result in an unhealthy amount of weight loss
Nat Rev Endocrinol 8:495502 Ferrannini E, Baldi S, Frascerra S, Astiarraga B, Heise T, Bizzotto R et al (2016a) Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
58 (2): p
Moreover, PGC1 suppressed metastasis of HCC cells by inhibiting the Warburg effect by means of the Wnt/-catenin/PDK1 axis, in a PPAR-dependent manner (Figure 4)
Among them, compound 8u becomes the most effective xanthine oxidase inhibitor, with an IC50 value of 0.0288 mM, which is equivalent to febuxostat (IC50 0.0236 mM) (Zhang et al., 2019)
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