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This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE G4 ) surface functionalized with lactate (LA) (PURE G4 -LA 24 ), to take advantage of glucose-dependent monocarboxylate transporters (MCTs) overexpression, loaded with selenium-chrysin (SeChry) and temozolomide (TMZ) or complexed with anti-glutaminase ( GLS1 ) siRNAs to abrogate glutamine dependence

Thank you There is a reason for the long gap between testing for Hughes as follows

Azevedo LF, Karpova NN, Rocha BA, Barbosa F, Gob GC, Carneiro MFH (2023) Evidence on Neurotoxicity after Intrauterine and Childhood Exposure to Organomercurials

(63(6)):524-528 doi:10.1002/jmd2.12319