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Evidence and Guidance Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda), are increasingly prescribed for type 2 diabetes and weight management

Neurobiol Dis 2006

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Among these, the incretin Glucagon-Like Peptide-1 (GLP-1), which is synthetized as proglucagon precursor peptide, then cleaved and secreted by L-cells disseminated in a proximal to distal gradient in the gut epithelium 1 , exerts insulinotropic actions and controls glucose metabolism by binding to the GLP-1 receptors (GLP-1R) highly expressed on pancreatic beta cells 2