First-in-human trial underway evaluating ATR-258's selective 2-adrenergic signaling in muscle Oral, first-in-class therapy aims to drive fat loss while preserving or increasing muscle mass Built on GRK2-biased signaling pathway to avoid traditional cardiovascular side effects Backed by 2025 Cell Press publication validating novel mechanism of action Signals growing momentum behind next-generation obesity therapies beyond GLP-1s ------------------------------------------------------------- Stay up to date with everything obesity through my newsletter To view or add a comment, sign in The ODYSSEY-#HCM findings were neutral from a clinical standpoint: Mavacamten use did not result in improved peak oxygen consumption or patient-reported health status in those with nonobstructive hypertrophic cardiomyopathy despite reverse remodeling as suggested by echocardiographic and plasma biomarker levels

Smaller and emerging players are targeting niche categories such as vegan formulations and cost-effective solutions for price-sensitive markets
Don't be shy about asking potential providers about their sterilization techniques and safety measures
Our findings unexpectedly reveal that phosphorylation of just a small part of the Med14 protein plays a significant role in the response to GLP-1 drugsand in the metabolic response to hormones more broadly, says Reuben Shaw, PhD, a professor and holder of the William R
Chronic gastrointestinal slowing does more than cause physical discomfortit can impact nutrient absorption, metabolic function, and overall systemic well-being