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They enhance glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite via central hypothalamic pathways, leading to lower energy intake and improved glycemic control
The majority of these follow-on patents were filed between 2021 and 2022, coinciding with the launches of Mounjaro and Zepbound (Figure 10)
Consider switching medications
Serious side effects requiring immediate medical attention include: Symptoms of acute pancreatitis (severe abdominal pain, sometimes radiating to the back) Signs of gallbladder problems (pain in the right upper abdomen, fever, yellowing of skin/eyes) Severe vomiting or diarrhoea leading to dehydration Sudden vision changes (which may indicate worsening diabetic retinopathy) Signs of serious allergic reactions (breathing difficulties, swelling of face/throat, severe rash) Other notable side effects include injection site reactions (redness, itching, or swelling at the injection site), fatigue, and hypoglycaemia, particularly when Mounjaro is used in combination with insulin or sulfonylureas
