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The opposing effects of mTOR signaling on apoptosis may depend on the distinct pro-apoptotic stimuli
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This is noteworthy as these analogues are at least 10-fold less potent then GLP-1-G 2 ( 1 ), meaning that even if at least 10 times more compound is required to get the same activity in vitro, they have a significant longer acting period
Adding glucagon receptor agonism changes the mechanism fundamentally
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