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doi:10.1089/jmf.2013.0145

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Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150

On the contrary, topical melatonin, as a stand-alone treatment, has decreased inflammatory markers and improved gingival index and pocket depth (13)

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