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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint
Reference: Krivic A, Majerovic M, Jelic I, Seiwerth S, Sikiric P
Vitamin B12 is also critical for neurological function
And theres a certain like muscle belly thats more conducive to looking bigger
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