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[28] Summary of the role of glutathione as a skin-lightening agent While there is no published data for intravenous glutathione, the results of the three randomized controlled trials mentioned above have provided grade Ib and 2b evidence in favour of the skin-lightening effects of topical and oral glutathione, with no significant adverse effects [Table - 1]
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Too much variation in either direction creates problems: Doses too far apart (9+ days): blood levels drop below the therapeutic threshold, reducing appetite suppression and glucose control Doses too close together (5 days or less): blood levels climb higher than intended, increasing nausea, vomiting, and other GI side effects The question "can I take it a day early" is really asking: how much timing flexibility exists before I create one of those two problems
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