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Common side effects include: In most cases taking L-carnitine supplement orally and properly as recommended (2g or less per day) is considered safe without any side effects
The clinical trials showed average weight loss of 1 to 2% body weight by week 4 and 5 to 6% by week 12
10.1042/BST20140319 152 SalvatoreT.GalieroR.CaturanoA.RinaldiL.Di MartinoA.AlbaneseG.et al (2022)
CletoASSchirloJMBeltrameMGomesVHOAcrasIHNeiverthGSet alSemaglutide effects on safety and cardiovascular outcomes in patients with overweight or obesity: a systematic review and meta-analysis
Potential risks include: Enhanced gastrointestinal side effects (nausea, vomiting, diarrhea, constipation) Increased risk of nutritional deficiencies and protein malnutrition Potential worsening of gastroesophageal reflux symptoms Dehydration risk and acute kidney injury, particularly during dose escalation Increased risk of gallbladder disease and complications Risk of intestinal obstruction or ileus Diabetic retinopathy progression in patients with diabetes, particularly with rapid glycemic improvement Hypoglycemia risk, particularly in patients on insulin or sulfonylureas Cost considerations and insurance coverage challenges Rare but serious risks including pancreatitis and thyroid C-cell tumors (boxed warning) Clinicians must engage in shared decision-making with patients, carefully weighing these potential benefits against risks in the context of individual patient circumstances, surgical outcomes, comorbidities, and treatment goals
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