Excessive APAP metabolism depletes glutathione and increases N-acetyl-p-benzoquinoneimide (NAPQI) levels, leading to oxidative stress, DNA damage, and cell necrosis in the liver, which in turn leads to liver damage
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The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient
Sikirics group has conducted extensive animal toxicology studies demonstrating no observed adverse effects, even at high doses across multiple species
