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Tumors with inherited or somatic deficiencies in HRR genes, such as BRCA1, BRCA2, PALB2, and RAD51, exhibit synthetic lethality to PARPis, including olaparib, rucaparib, niraparib, and talazoparib, which have shown durable efficacy in BRCA-mutant breast, ovarian, and prostate cancers
Moreover, excess copper stabilizes HIF-1 by inhibiting its ubiquitination and degradation, forming a positive feedback loop that reinforces cuproptosis resistance
Several of those together warrant a GP visit
10.1093/humrep/15.4.806
Glutathione IV therapy offers a way to support these processes through targeted antioxidant support
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