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Some also report worsening acid reflux or new symptoms of gastroesophageal reflux disease (GERD)

For those with type 2 diabetes, particularly when combined with other diabetes medications, GLP-1's may increase the risk of hypoglycemia (low blood sugar)

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Participants who received semaglutide injections lost significantly more weight than those on the placebo, with an average weight loss of around 15% of their initial body weight over the study period