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Here, we show that replacement of a single amino acid at position 973, just distal to the NPEY motif in the intracellular juxtamembrane region, from leucine, which is highly conserved in IRs, to phenylalanine, the highly conserved homologous residue in IGF1Rs, resulted in decreased IRS-1/PI3K/Akt/mTORC1 signaling and increased Shc/Gab1/MAPK cell cycle signaling
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doi: 10.1038/s41419-021-04326-y 86 WangYZhuXYuanSWenSLiuXWangCet al
This may partially explain why cysteine is reported as a risk factor for cardiovascular disease in hyperlipidemic patients (Jacob et al, 1999), and why cysteine is related to several factors that take part in the cardiovascular risk profile (El Khairy et al, 1999)