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These effects are thought to be mediated through cAMP/PKA signaling downstream of the GLP-1R, leading to suppression of NF-B activation and reduced STAT3 transcription factor phosphorylation
It stimulates POMC neurons (which suppress appetite) and inhibits NPY/AgRP neurons (which stimulate hunger)
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Effects on Fibrosis (Tissue Stiffness) Fibrosis is a hallmark of lipedema and contributes to: Pain Tissue hardness Reduced response to treatment Tirzepatide has shown antifibrotic effects in other conditions (like fatty liver disease), suggesting it may help improve tissue quality over time
Glutathione-infused moisturizers : To lock in moisture, apply a glutathione-infused moisturizer after the serum
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