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Many patients can safely continue GLP-1 medications with appropriate precautions, but the decision depends on individual risk factors including dose escalation status, gastrointestinal symptoms, and type of surgery

Despite these limitations, the inclusion of large, high-quality randomised controlled trials supports the overall reliability of the findings

In in-vivo and in-vitro models, Tesamorelin has demonstrated dose-dependent increases in GH and downstream insulin-like growth factor 1 (IGF-1) production, enabling detailed study of the GH/IGF-1 axis

A number of clinical studies established that GHK-CU stimulates the synthesis of collagen, the production of selected glycosaminoglycans (like hyaluronic acid), and modulates matrix metalloproteinases (MMPs)

Furthermore, recovery of BDNF levels results in the improvement of neuroplasticity and reduction of neuronal apoptosis (Kraus et al., 2017)