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Indeed, as it will be discussed below, serious concerns had been repeatedly raised on the actual PAC safety (Brune et al., 2015
Bioorg Med Chem 94:117479
People with heart disease should be cautious, as very high doses may raise Trimethylamine-N-oxide (TMAO), a compound linked to cardiovascular risk
It is noteworthy that GLP-1 RAs are contraindicated in pregnancy and breastfeeding
Lancet Diabetes endocrinol (2019) 7(10):77685
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