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They can improve blood pressure, lipid profiles, and endothelial function, which are crucial for a healthy cardiovascular system and reducing cardiovascular risk factors
The Leerink analysts expect CagriSema to demonstrate best-ever weight loss any day now, adding that we expect at least high-20% weight loss. Still, CagriSema could pose practical challenges for Novo, particularly in terms of commercialization
Moreover, small-molecule GLP-1RAs offer a solution to the bioavailability limitations faced by oral peptide-based agents, which often depend on absorption enhancers (e.g., SNAC) and strict fasting protocols [74]
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